Ipamorelin
Ipamorelin is deemed one of the safest GHRPs (growth hormone releasing peptide) since it stimulates GH release from the pituitary gland without appetite stimulation or an increase in cortisol, acetylcholine, prolactin and aldosterone as seen with other peptides in its class. It is unique because it also stimulates IGF-1 production in the liver independent of GH levels. It is highly potent and has demonstrated good safety and tolerability in human clinical studies. Some of its known benefits include:
- anti-aging
- anti-inflammatory
- muscle building
- fat reduction
- strengthen bones
- healthy joints and ligaments
- Cognition, focus and memory
- improved skin quality
- Better mood
- energy and vitality
- better sleep
- accelerated weight loss
- increased libido
- long-term growth hormone production
Dosing
Usual anti-aging starting dose is a subcutaneous 200mcg once a day at bedtime, 5 days a week.
Pricing
Contact for pricing.
Ready to optimize your health?
Ipamorelin Clinical Information
Mechanism
Ipamorelin is a selective ghrelin receptor (GHSR) agonist that stimulates the body’s own pituitary to release growth hormone in a physiologic, pulsatile pattern. Unlike older GHRPs, it does not meaningfully affect cortisol, prolactin, or appetite.
Common Uses
- Recovery and sleep quality
- Body composition support over months
- Adjunct in anti-aging and longevity protocols
- Standard pairing with CJC-1295 (synergistic GH release)
Dosing
Typically 100–300 mcg subcutaneously at bedtime, often combined with CJC-1295. Cycle 3–6 months, with breaks.
Side Effects
- Injection-site reactions
- Vivid dreams (related to deeper sleep)
- Mild head flush early after injection
- Water retention at higher doses
Contraindications
- Active malignancy
- Pregnancy or breastfeeding
- Severe insulin resistance (monitor)
- Active carpal tunnel symptoms
Medically reviewed by: Diana Medina, MMS, PA-C — Florida-licensed Physician Assistant
Medical Director: Luis Campillo, MD
Last reviewed: May 20, 2026
This page is for educational purposes only and does not constitute medical advice. All treatments require an individualized medical evaluation. DMHealth provides services via telehealth to Florida residents under the medical supervision of Luis Campillo, MD, in accordance with Florida Statutes § 458.347 governing physician assistant practice. Some statements have not been evaluated by the U.S. Food and Drug Administration; products mentioned are not intended to diagnose, treat, cure, or prevent any disease.