MOTS-C
MOTS-c is a small peptide that has been shown to have anti-aging effects. It is produced by mitochondria, which are the powerhouses of cells responsible for producing energy.
It improves mitochondrial function, increases insulin sensitivity, and enhances glucose uptake in cells. These effects help with aging by reducing the risk of age-related diseases such as diabetes, cardiovascular disease, and neurodegenerative disorders.
MOTS-c has been shown to increase muscle strength and endurance in both mice and humans. This is extremely beneficial for older adults who may experience age-related muscle loss and weakness, known as sarcopenia.
MOTS-c is a bioactive peptide that regulates gene expression and Cellular Metabolism.
- Stimulates glucose utilization evidenced by increased glucose clearance and lactate accumulation in culture media.
- Coordinates Cellular Glucose, Mitochondrial, and Fatty Acid Metabolism
- Prevents high fat diet-induced obesity by increasing energy expenditure, including heat production, and improving glucose utilization and insulin sensitivity.
As such, MOTS-c has implications in the regulation of obesity, diabetes, exercise, and longevity, representing an entirely novel mitochondrial signaling mechanism to regulate metabolism within and between cells.
Dosing
RECONSTITUTE WITH 1ML BACTERIOSTATIC WATER. INJECT 1ML (10mg) SQ WEEKLY.
Pricing
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MOTS-c Clinical Information
Mechanism
MOTS-c is a 16-amino-acid mitochondrial-derived peptide that activates AMPK and supports metabolic flexibility. Levels decline with age, paralleling mitochondrial decline.
Common Uses
- Insulin sensitivity and metabolic optimization
- Exercise performance and recovery
- Adjunct in longevity protocols
Dosing
Typically 5–10 mg subcutaneously 3x/week, on training days when possible. Cycle 8–12 weeks with breaks.
Side Effects
- Mild injection-site reactions
- Occasional brief fatigue early in protocol
- Mild GI changes
Contraindications
- Pregnancy or breastfeeding
- Severe uncontrolled diabetes (monitor closely if used)
- Known allergy to formulation
Medically reviewed by: Diana Medina, MMS, PA-C — Florida-licensed Physician Assistant
Medical Director: Luis Campillo, MD
Last reviewed: May 20, 2026
This page is for educational purposes only and does not constitute medical advice. All treatments require an individualized medical evaluation. DMHealth provides services via telehealth to Florida residents under the medical supervision of Luis Campillo, MD, in accordance with Florida Statutes § 458.347 governing physician assistant practice. Some statements have not been evaluated by the U.S. Food and Drug Administration; products mentioned are not intended to diagnose, treat, cure, or prevent any disease.