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Tirzepatide is unique because it’s the first combination of two classes of medications: a glucagon-like peptide-1 (GLP-1) receptor agonist and a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. Tirzepatide is known as a dual GLP-1/GIP receptor agonist. As a dual-acting peptide, Tirzepatide stimulates insulin secretion, inhibits glucagon secretion, slows down gastric emptying and increases satiety. It signals to the brain that you’re full — so you eat less. It slows the movement of food through your stomach — so you feel full longer.

Like Semaglutide, it is usually given as a weekly injection. Other similar injectable weight loss medications only mimic one incretin — GLP-1. Because tirzepatide acts like two incretins, it can cause more weight loss than current alternatives.



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Tirzepatide vs Semaglutide

  • Both are FDA approved
  • Both are classified as GLP-1 receptor agonists, which means they work by mimicking the effects of a naturally occurring hormone in the body that helps regulate blood sugar and appetite.
  • Both medications have been shown to be very effective in promoting weight loss in clinical trials
  • Tirzepatide is known as a dual-acting peptide, since it is a GLP-1 and a GIP receptor agonist
  • Tirzepatide is a newer medication and has been shown to be more effective in promoting weight loss compared to semaglutide (in clinical trials, patients taking tirzepatide lost on average about twice as much weight as patients taking semaglutide).

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